TP53 p.Arg337His geographic distribution correlates with adrenocortical tumor occurrence
نویسندگان
چکیده
منابع مشابه
Occurrence of Neuroblastoma among TP53 p.R337H Carriers
The high incidence of adrenocortical tumors and choroid plexus carcinoma in children from South and Southeastern regions of Brazil is associated with the germline p.R337H mutation of TP53 gene. The concomitant occurrence of neuroblastoma and adrenocortical tumors in pediatric patients harboring the p.R337H mutation at our institution prompted us to investigate the putative association between p...
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Introduction: Each year, 10 million people are faced with cancer and about 6 million of them die throughout the world. This study aimed at investigating the geographical distribution of cancer and its environmental risk factors in Iran. Methods: The present study was mapping the available data collected from the reports of Iranian Center for Disease Control (Cancer Bureau) regarding the frequen...
متن کاملSomatic TP53 mutations are relatively rare among adrenocortical cancers with the frequent 17p13 loss of heterozygosity.
PURPOSE Allelic losses [loss of heterozygosity (LOH)] at the 17p13 locus are frequent (85%) in adrenocortical cancers. The tumor suppressor gene TP53 is located at 17p13. The aim of the study was to determine the frequency of TP53 somatic inactivating mutations in adrenocortical tumors with 17p13 LOH and their clinico-biological correlations. EXPERIMENTAL DESIGN TP53 somatic mutations, intrag...
متن کاملPenetrance of adrenocortical tumours associated with the germline TP53 R337H mutation.
BACKGROUND An inherited germline P53 mutation has been identified in cases of childhood adrenocortical carcinoma (ACT), a neoplasm with a high incidence in southern Brazil. The penetrance of ACT in carriers of the point mutation, which encodes an arginine-to-histidine substitution at codon 337 of TP53 (R337H), has not been determined. OBJECTIVE To investigate the penetrance of childhood ACT i...
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The geographic distribution of Astragalus (Fabaceae) in Iran was analyzed using a database of 7606 georeferencedobservations. Astragalus occurs in all provinces of Iran, but 88% ofthe observations are in five provinces including Tehran, West-Azerbaijan, Esfahan, Kordestan, and Khorasan-e Razavi.Most species are rare and narrowly endemic: Thelargest distance between two observations of the same ...
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ژورنال
عنوان ژورنال: Molecular Genetics & Genomic Medicine
سال: 2020
ISSN: 2324-9269,2324-9269
DOI: 10.1002/mgg3.1168